Title : In - silico fine - mapping : narrowing disease - associated loci by intergenomics Authors :

نویسندگان

  • Pablo Serrano-Fernández
  • Saleh M. Ibrahim
  • Dirk Koczan
  • Uwe K. Zettl
  • Steffen Möller
چکیده

Summary: Genetic linkage and association studies define quantitative trait loci (QTLs) and susceptibility loci (SLs) that influence the phenotype of polygenic traits. A web-accessible application was created to identify intergenomic consensuses to fine map QTLs and SLs in silico and select particularly promising candidate genes for such traits. Furthermore, this approach offers an empirical evaluation of animal models for their applicability to the study of human traits. Availability: http://qtl.pzr.uni-rostock.de/qtlmix.php

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تاریخ انتشار 2004